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This is mechanistically linked to improved adipocyte insulin signaling, reduced pro-inflammatory cell infiltration, the recruitment of pathways for lipid storage and oxidation, and the release of insulin-sensitizing adipokines [49]

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Subjects were either given exenatide injections under the skin for 12 months or served as controls

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During follow-up, 6 new glucose-lowering medications were used in the liraglutide group and 3 new glucose-lowering medications in the placebo group

169 Chronic hyperglycemia decreases the complexity and differentiation of 3xTg-AD newborn neurons and depressed synaptic facilitation, accompanied by defective hippocampal-dependent memory, 109 suggesting that diabetes promotes changes in AD neurogenesis that ultimately exacerbates cognitive impairment