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If nausea, abdominal pain or sustained fast heart rate occur, contact your prescriber

[4] [6] This relationship is bidirectional and complex, involving: Inflammatory pathways that affect both metabolic and mental health Hormonal dysregulation impacting mood and stress responses Psychosocial factors including stigma, body image concerns, and chronic disease burden Lifestyle factors such as reduced physical activity and poor sleep quality When GLP-1 medications improve glycaemic control, facilitate weight loss, and enhance overall metabolic health, patients may experience secondary improvements in psychological wellbeing

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Likewise, L-lactate indirectly suppresses ferroptosis by inactivating AMPK, which in turn upregulates SREBP1/SCD1 signaling and promotes the synthesis of anti-ferroptotic MUFAs (65)

Activating these pathways may heighten taste intensity and alter how food cues are valued, dampening hedonic drive