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Compounding pharmacies faced mandatory shutdown deadlines

Taking extra doses increases the risk of serious adverse events including severe gastrointestinal distress, pancreatitis, and unpredictable blood sugar changes

In September 2025, the FDA sent thousands of warning letters and issued approximately 100 cease-and-desist letters to companies regarding their use of misleading direct-to-consumer pharmaceutical advertisements. The agency also published a green list of acceptable GLP-1 compounding ingredients intended to regulate ingredient sourcing and reduce the risk of unsafe compounded products

Both the Lilly and Novo Nordisk pills resulted in less weight loss than the average achieved with Lilly's injectable Zepbound, which results in a 21% average weight loss, or Novo Nordisk's injectable Wegovy, which averages about 15%