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Oral delivery of peptides faces inherent challenges due to enzymatic degradation in the gastrointestinal tract, and sublingual absorption offers a partial workaround by allowing the peptide to enter the bloodstream through the mucous membranes under the tongue

PMID: 39724960 Bioconjug Chem Development of a Long-Acting and Stapled Dual Amylin and Calcitonin Receptor Agonist as Monotherapy and Combination with GLP-1R Agonists for the Treatment of Obesity

There is another mechanism showing that GLP-1RA treatment regulates Ca 2+ levels due to reductions in the ryanodine receptor (RyR)2 phosphorylation and suppression of the activation of calmodulin-dependent protein kinase (CaMK)-II [77]

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LiYPerryTKindyMSHarveyBKTweedieDHollowayHWet al

5.1 DPP-IV inhibitors The scientific basis for their therapeutic utility in the context of cancer treatment lies in their multifaceted actions on various physiological processes