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Many people experience nausea, early fullness, bloating, reflux, constipation, or diarrhea, especially when starting the medication or increasing the dose

Dose titration of GLP-1 receptor agonists should follow manufacturer recommendations, typically starting at the lowest dose and increasing gradually every 4 weeks based on tolerability and glycaemic response

A 2025 study in mice showed that prenatal glyphosate exposure at normal levels reshapes the gut microbiome

Any considerations outside of this age range would need to be specifically determined by a licensed clinician on a case-by-case basis

Gastroenterology 137 , 445452 (2009)

The schedule can be slowed if needed