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Ca2+ entering the cytoplasm can activate the Ca2+ dependent protein kinase, which together with cytochrome c induces the onset of apoptosis (65)

Regular monitoring of blood glucose, particularly if symptoms are recurrent, can provide valuable information to guide treatment adjustments

These findings emphasize the need to reconsider the CNS bioavailability of GLP-1RAs and to investigate alternative delivery strategies (e.g., intranasal administration) and molecular designs that improve brain penetrance