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Variability in CNS penetrance, receptor signaling bias, and the potential for neuropsychiatric side effects warrant careful patient selection and compound-specific evaluation
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Thus, we modified GEP44 with the intent of also reducing its capacity to induce internalization at the GLP-1R

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Larger, well-designed randomized controlled trials with longer follow-up are essential to confirm efficacy, better define the long-term safety profile, and establish cost-effectiveness before GLP-1 RAs can be recommended as part of routine smoking cessation programs [,]

Ganju said
