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Compared to those receiving neither medication, all-cause mortality was significantly lower among patients treated with SGLT2-I only (HR 0.28, 95% CI 0.270.29), GLP-1RA only (HR 0.39, 95% CI 0.370.40) and both agents (HR 0.17, 95% CI 0.160.18)

While the study showed that GLP-1 agonists are associated with decreased risks of certain severe health outcomes like pneumonia, suicidal ideation, and alcohol use disorder, they may increase the risk of other outcomes, including gastroesophageal reflux disease, nausea/vomiting, and sleep disturbances

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