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The GLP-1R has itself several LoF variants including R380C, shown by two independent groups to have normal surface expression but reduced affinity for Exenatide (Wootten et al., 2016

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[5] [15] The FDA and manufacturer Eli Lilly continue to monitor safety signals through ongoing pharmacovigilance activities

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Q3: Is there a connection between GLP-1 drugs and suicidal thoughts

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