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Receptor activation Despite the existence of unique structural features among the ligand-binding pockets of GIPR, GLP-1R and GCGR, both tirzepatide and peptide 20 triggered receptor conformational changes similar to that induced by GLP-1 or GCG 4,27 and distinct from the inactive or apo GLP-1R and GCGR structures (Supplementary Fig

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GLP-1 also slows gastric emptying, contributing to a longer feeling of fullness after meals and slower digestion of food, which helps moderate blood sugar levels