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What began with the isolation of Exendin-4 has evolved into a sophisticated era of multi-receptor poly-agonists

Impulsivity derived from the dark side: neurocircuits that contribute to negative urgency

When the key (agonist) binds to the lock (receptor), it opens the door (activates the receptor) to produce a specific effect

Mol Metab 30:72130 Kabahizi A et al (2022) Glucagon-like peptide-1 (GLP-1) signalling in the brain: from neural circuits and metabolism to therapeutics

Liraglutide reduces alcohol consumption, anxiety, memory impairment, and synapse loss in alcohol dependent Mice

However, when combined with large or fatty meals, the slow emptying can cause nausea or discomfort