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When scientists isolated it from Gila monster saliva in the early 1990s, they noticed something remarkable: it closely resembled GLP-1, or glucagon-like peptide-1, which the human body naturally produces to regulate blood sugar and appetite

It regulates: Satiety signaling Insulin secretion Gastric emptying Postprandial glucose response Energy partitioning This is why the idea that the microbiome controls appetite is better understood as microbiome-influenced appetite signaling, where microbial metabolites may help shape satiety, gastric emptying, and metabolic response

doi: 10.1038/nrneurol.2016.133 26 CadwellC

Borrelli E, Bandello F, Boon CJF, et al

Structural pharmacology and mechanisms of GLP-1R signaling