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Data mining has not shown signals of association with mood disorders

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In a study of transgenic mice with a Kras G12D mutation which induces PanINs and eventually pancreatic cancer, treatment with exendin-4 increased higher grade PanIN lesions (35, 38)

Este efecto se descubri posteriormente cuando los pacientes diabticos mostraban prdidas de peso significativas, comparado con medicamentos como la Metformina que solo reduca el peso entre un 3-5%

Overall, GLP-1 RAs appear promising as adjunctive therapies for HS and psoriasis, especially in patients with coexisting metabolic disease

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