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This work was supported in part by NIH grants K01DK093657 (JMH), R03DK110270 (JMH), and Baylor College of Medicine seed funding (RAB)

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Some experts have raised concerns about where compounding facilities find semaglutide if Novo Nordisk, its sole manufacturer, isnt providing the active ingredient

Wootten et al., 2013c), but the equivalent mutation in rat GLP-1R had no major effect (Xiao et al., 2000)

Patients with a history of thyroid cancer or multiple endocrine neoplasia should avoid these medications entirely

Brand-name Contrave runs $200-300 per month, though the individual components (generic bupropion and naltrexone) can be prescribed separately for significantly less