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Furthermore, representatives of both, bile acid analogues and non-steroidal FXR agonists like nidufexor (Tully et al., 2017) are under clinical investigation for treatment of NAFLD and NASH (Schuck et al., 2014

Youd end up skinny fat, lighter on the scale but weaker and softer than before

Because these studies allow for concomitant insulin adjustments, and they lack a controlled group (i.e., placebo) interpretation of the A1c reduction is very difficult

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Both compounds target combined-incretin-axis pharmacology but through different molecular strategies