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SGLT2 and SGLT2is The sodium-glucose cotransporter 2 (SGLT2) is located in the apical membrane of the S1 and S2 segments of the proximal tubule and is responsible for 90% of glucose and sodium reabsorption [83]
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Regarding pancreatic beta cell defects, there are particular needs to restore first-phase glucose-induced insulin release and improve proinsulin-to-insulin processing, as neither problem is adequately addressed by existing therapies