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GLP-1RAs contribute to metabolic adjustments in MASLD by controlling fat deposition, inflammation, and potentially fibrosis

It produces butyrate, a short-chain fatty acid that may help keep the gut barrier strong and support healthy immune function

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Rev Endocr Metab Disord 15(3):181187 van Bloemendaal L et al (2014) GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans

Experimental evidence demonstrated that treatment with (Ex-4)2-Fc promotes the conversion of pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages, leading to increased expression of anti-inflammatory factors and significant reductions in pro-inflammatory markers