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This shift from "Large Molecule/Biologic" to "Small Molecule/Chemical" changes everything: Easier Synthesis: They are produced via standard chemical synthesis rather than complex biological fermentation or solid-phase peptide synthesis (SPPS)

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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor