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Ohbayashi K, Oyama Y, Yamaguchi C, Asano T, Yada T, Iwasaki Y

doi: 10.12688/f1000research.20602.1 227 LaffertyRAOHarteFPMIrwinNGaultVAFlattPR

Incorporation of a trifluoromethyl group at the 6-position of the tetrahydropyran ring in omarigliptin (with a (2R, 3S, 5R, 6S) configuration) was found not only to enhance the pharmacokinetic profile in mice but also to maintain robust DPP-4 inhibitory activity

Soares C

Arr recruitment at the GLP-1R leads to internalization of the receptor toward endosomal compartments, which has been proposed to impact receptor desensitization and signaling duration in preclinical models ( 18, 19 )

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