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Very interesting paper providing cardiologists point of view on the comparison of semaglutude and tirzepatide They conclude that semaglutide currently remains the most established option for reducing cardiovascular risk in patients with T2DM and obesity with atherosclerotic disease Tirzepatide is particularly well suited when maximal weight reduction represents the primary clinical objective. It needs to be noted that the review was published before publication of results of SURPASS-CVOT were tirzepatide demonstrated non-inferiority vs

Methods In 10,310 participants from the Atherosclerosis Risk in Communities (ARIC) Study (aged 4670 years, ~55% women, ~20% Black adults) without diabetes at baseline (19901992), we used Cox regression to characterise age- and sex-adjusted associations of prediabetes with ~30 year incidence of complications (composite and separately), including atherosclerotic CVD (ASCVD), heart failure, chronic kidney disease (CKD) and all-cause mortality before and after accounting for intervening incidence of diabetes, modelled as a time-varying variable