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The incidence of type 2 diabetes has also been rising throughout the world in the past decades, with this trend of increase stabilizing and even reversing in some populations only in the last 20 years (Magliano et al., 2019)

doi: 10.1152/ajpendo.00298.2019

A central insight emerging from the GLP-1 experience is that biological pleiotropy does not preclude therapeutic utility

This suggests that there may not be a functional link between peripheral GLP1 and central GLP1 release, as that would require an excitatory effect on PPG neurons that should induce cFos expression

Ghanem recommended seeking out professionals and practices who take a "holistic approach" to weight loss, offering mental health support in addition to medication