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Importantly, comorbid T2DM or elevated peripheral IR accelerate disease progression in AD and PD independently of vascular disease, with higher peripheral IR predicting conversion from mild cognitive impairment to AD (12, 13) and faster motor and cognitive decline in PD (14, 15), thereby implicating IR as a modifier of NDD biology rather than a simple comorbidity

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The emerging story of GLP-1 agonists and migraines is part of a larger narrative about how metabolic drugs are revealing connections between body systems that were previously studied in isolation