retatrutide phase 3 trial Diabetes Dialogue: Reduces Body Weight 28.7% in retatrutide #obesity #osteoarthritis #clinicaltrials #medicine

, & Krashes, M

Significance : This trial evaluated what happens when semaglutide is discontinued after initial weight loss, providing critical data on maintenance requirements

Glucagon-like peptide-1 (GLP-1) drugs mimic the GLP-1 hormone, which helps control insulin and blood sugar levels, decreases appetite and slows digestion of food

Retatrutide is still investigational, has not been approved by regulators and cannot legally be prescribed or supplied as a weight loss treatment

What the BBB non-accreditation means BBB accreditation is not mandatory

Although the substitution of C236 3.39b appeared to have minimal effects on GLP-1 pharmacology, the mutation of the conserved C226 3.29b in two studies led to either no detectable activity or a 25-fold reduction in GLP-1 affinity with 38-fold lower potency