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GLP-1 RAs are contraindicated with personal or family history of MTC or in patients with MEN2

Importantly, headaches rarely led to treatment discontinuation, suggesting that most patients found them manageable with appropriate support

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Aroda VR, Rosenstock J, Terauchi Y, Altuntas Y, Lalic NM, Morales Villegas EC, et al

Retatrutide in Type 2 Diabetes The Lancet 2023 Trial This foundational trial evaluated retatrutide across a wide dose range in patients with type 2 diabetes

However, gene duplication would mean an increase in gene dosage, which would likely be deleterious as insulin release and glucose tolerance is sensitive to GLP-1 dosage 38,39