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-1.86%) and weight loss (-5.4, -7.6, -11.2 kg vs
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NICE recommendations for type 2 diabetes management (NG28) emphasise: Lifestyle modification as the foundation: structured education (such as DESMOND), dietary changes, weight management, and physical activity Metformin as the first-line pharmacological treatment in most cases A stepwise approach to medication intensification based on individualised HbA1c targets Regular monitoring and cardiovascular risk reduction Berberine does not feature in these guidelines because there is insufficient evidence from large-scale, long-term trials conducted in UK populations to demonstrate its safety, efficacy, and cost-effectiveness compared to licensed treatments
If the main mechanism by which GLP-1 medications help fibromyalgia is through weight loss, this could matter, but individual responses to both medications vary considerably
One thing to consider is that most insurance plans do not cover GLP-1 medications for weight loss, and these medications can be very expensive
