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Compounded and FDA-approved medications are not interchangeable

An exploratory mediation analysis of the effects on kidney outcomes (composite of macroalbuminuria, decreased GFR, renal death) with liraglutide and semaglutide in patients with T2DM in the LEADER and SUSTAIN-6 trials observed that HbA1c mediated 2526% and SBP 922% of kidney effects with a negligible contribution of the other parameters studied, such as body weight [15]

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These medications can help qualified patients, but results depend on nutrition, activity, dose tolerance, side effects, refill access, and realistic long-term planning

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