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In the future, physicians should pay attention to the relationship between GLP-1 RA use and the risk of respiratory diseases and evaluate the efficacy of GLP-1RAs in the primary and secondary prevention of respiratory diseases
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Removing the lipedema fat does slow the progression of disease and disability

These pleiotropic effects support a paradigm shift from organ-specific treatment toward an integrated, pathophysiology-driven approach in CKM syndrome, positioning GLP-1 RAs as a cornerstone therapy for comprehensive cardiometabolic risk reduction

The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention

Ueda and colleagues found that 77 suicide deaths occurred among GLP-1 receptor agonist users and 71 among SGLT2 inhibitor users during a mean follow-up period of 2.5 years
