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For semaglutide users with reduced appetite, this may mean prioritizing protein at the beginning of each meal when hunger signals are strongest

Some individuals can meet protein targets by supplementing with high-protein shakes, bars, and other fortified products [150]

Suggested Titration Schedule Based on the phase 2 clinical trial protocol

[130] In metabolic dysfunction-associated steatohepatitis (MASH), a phase 3 trial published in April 2025 showed semaglutide 2.4 mg weekly achieved MASH resolution without worsening fibrosis in 63% of participants with moderate to advanced fibrosis, versus 34% on placebo, over 72 weeks

doi: 10.1016/S1474-4422(20)30231-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 150.Ciarmiello A, Giovannini E, Riondato M, et al

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