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For example, glucose is absorbed by the intestine and enters the portal vein, where glucose sensing increases hepatic vagal signaling to the NTS 52 and subsequently to the hypothalamus 53 to decrease food intake 54,55 and regulate glycemia 56,57

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In reality, meals built around fiber-rich whole foods often increase fullness because they combine volume, water, fiber, and slower digestion

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Kathleen Valenton, a board-certified OB-GYN and Lemme medical advisory board member, via email