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Based on a sensitivity analysis with a maximum 5-year follow-up time, exposure misclassification introduced by long follow-up times might explain only partly this null association

A recent study further demonstrated that the suppression of hepatic glucose production, measured via the clamp technique using tracer glucose, was accompanied by a reduction in glucagon levels and increased insulin secretion in subjects with type 2 diabetes administered 100 mg of vildagliptin (55)

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In contrast to the results in rodents, in vivo animal studies with cynomologus monkeys did not show any liraglutide-induced calcitonin release or any effect on relative C-cell fraction in the thyroid gland after 87 weeks at doses up to 60-fold higher than the highest dose recommended in humans [169]

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