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Saldvar-Cern HI, Vargas-Camacho JA, Len-Cabrera S et al (2025) Oral small-molecule GLP-1 receptor agonists: mechanistic insights and emerging therapeutic strategies
It reflects the combination of rapid weight loss, reduced caloric intake, and metabolic adjustment rather than any direct toxic effect of the compound

Clinic data suggests patients on sermorelin + GLP-1 preserve significantly more muscle than those on GLP-1 alone, with particular benefit for patients over 40 whose GH is already declining

Aim for 0.8 to 1 gram per pound of goal body weight daily (or 1.2 to 1.6 g/kg)
Watch portion sizes to prevent overeating

J Nutr 151: 14971506, 2021