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That changed in 2025 with the publication of SURMOUNT-5, the first randomized head-to-head trial, published in the New England Journal of Medicine

While some progress is being made linking the gut microbiome with obesity and T2D (Perry et al., 2016

When considering weight loss injections alongside methotrexate, several safety considerations warrant careful attention

M., Eisenberg, J

[Google Scholar] [17].Fernndez-Ruiz I, SELECT shows cardiovascular risk reduction with weight-loss drug semaglutide in people without diabetes, Nature Reviews Cardiology (2023)

However, since these adverse events are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency, the spokesperson said in a Wednesday email