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Semaglutide is a peptide that is metabolised via proteolytic cleavage and does not rely on cytochrome P450 enzymes, which are responsible for metabolising many oral medications
compounded oral and sublingual formats don't replicate that pharmacokinetic profile

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Mallinson CN, Bloom SR, Warin AP, Salmon PR, Cox B

Approximately 15-20% of patients who experience side effects on injections find oral semaglutide more tolerable

making it an essential part of your weight management journey
