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A few highlights: Accelerated eGFR decline during the year preceding a heart failure event Slower decline afterward but still exacerbated A parallel between eGFR slope and NYHA class, suggesting the kidney may be signaling congestion early These findings call for a shift in practice: instead of relying on static eGFR thresholds, tracking its trajectory over time could help us identify at-risk patients sooner and intervene before hospitalization

effector concentration for half-maximum response) and maximal efficacy ( E max (%)) of peptides relative to the reference ligand Ex4 (Table 1)

10.3389/fendo.2022.910256 [DOI] [PMC free article] [PubMed] [Google Scholar] 78.Shi W, Zhang W, Zhang D, Ren G, Wang P, Gao L, et al

Gastrointestinal and Gallbladder Effects Gastrointestinal symptoms are usually dose-related and may be mitigated by slower titration and taking smaller, lower-fat meals during the first weeks

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Sodium-Glucose Co-transporters and Their Inhibition: Clinical Physiology