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Reporting suspected side effects even when causality is uncertain contributes to the collective understanding of a medicine's safety profile

So, lets break it down

Short half-life agents (exenatide twice daily or lixisenatide) produce spikes with transient increases in plasma arGLP-1 levels, resulting in intermittent activation of the receptor and have a potent effect on gastric emptying and postprandial glycemia by reducing the rate of glucose entry into the duodenum

More difficult to self-administer without assistance

daily) Presence of GI symptoms (nausea, vomiting, abdominal pain, constipation)

These challenges may strain relationships and impact marriage satisfaction