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GLP-1's roles in the body include: Stimulating insulin secretion from the pancreas in a glucose-dependent manner Suppressing glucagon (which otherwise drives the liver to release stored glucose) Slowing gastric emptying, which prolongs feelings of fullness Signaling satiety centers in the brain to reduce appetite Supporting healthy blood glucose levels already in the normal range GLP-1's challenge is that it has a very short half-life in the bloodstream (typically just 2 minutes) before an enzyme called DPP-4 breaks it down

GLP-1/GIP, GLP-1/glucagon, and even triple agonists are the dominant focus, though the spectrum extends to other mechanisms as wellamylin, GIP antagonism, NK2 receptor agonism, and more, said DiMarchi Looking further ahead, DiMarchi sees potential for oral therapies, including oral peptides

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