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doi: 10.1016/j.molmed.2015.09.001

Also nicknamed twincretin, tirzepatide is a dual GIP/GLP-1 receptor agonist (GLP-1 RA) that works by activating the GIP and GLP-1 receptors, enhancing insulin secretion in response to glucose intake, decreasing glucagon levels, improving insulin sensitivity, decreasing food intake, and slowing gastric emptying

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In addition, cohort studies support that long-term usage of metformin decreases the risk of early-onset prostate cancer in age groups less than 65 [97]

Triglycerides change (percent): The results demonstrated a significant reduction in triglycerides between orforglipron 36 mg and orforglipron 12 mg (MD = -5.21, 95% CI (-8.21