jardiance a glp 1 Eli Lilly, Boehringer hit FDA roadblock in quest to repurpose for Type diabetes FDA says no to Lilly,

Semaglutide could regulate miR-5120/ABHD6 expression through GLP-1R

Diabetes 62: 2595-2604, 2013

Phase 3 trials (the TRIUMPH program) are currently underway (Jastreboff et al., NEJM, 2023)

Rodent studies showed thyroid C-cell tumours at high doses, but human trials have not demonstrated increased thyroid cancer incidence over follow-up periods of 25 years

I'm not saying that necessarily exactly applies here, but in some cases it's a similar concept because some of those benefits are going to be intangible or very difficult to quantify around how this contributes to building a culture of health, of wellbeing, of where folks feel valued, right

The clinical approach remains the same regardless of which GLP-1 medication you're on: proactive nutrient monitoring, adequate protein, and patience through the self-resolving TE cycle