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Ongoing monitoring Track any close-out letter (if issued, it signals FDA recognition of remediation) and watch for escalated enforcement across peers

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Constipation and other digestive changes can persist longer than nauseasometimes continuing for four to eight weeksbecause they reflect the medication's effect on gastrointestinal motility

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Missed Dose: If you miss a dose, take it as soon as you remember, provided it is within five days of the missed dose

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Laboratories that standardize these variables and record them consistently often see improved run to run comparability

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Physiol Rev 87: 1409-1439, 2007

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