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This dehydration leads to pre-renal azotemia and acute kidney injury, particularly in subjects who are concurrently taking medications that alter renal hemodynamics, such as renin-angiotensin system inhibitors (ACE inhibitors or ARBs) or diuretics

Both optogenetic and chemogenetic GLP-1-producing PPG neuron activation in rats leads to a robust ingestive behavior suppression, with a similar effect size between males and females (51)