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Effect of Metformin and exenatide on pregnancy rate and pregnancy outcomes in overweight or obese infertility PCOS women: Long-term follow-up of an RCT

Reduce if gastrointestinal symptoms remain severe after six or more weeks at a given dose level, if significant dehydration results from persistent vomiting or diarrhea, if heart rate increases beyond 15 beats per minute above baseline, or if the side effect burden is causing protocol abandonment

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They reduced their training volume without abandoning intensity