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Indeed, dual GLP-1 ligands that activate the GLP-1R but simultaneously block the GIPR (AMG133 or maridebart cafraglutide, MariTide ) are currently in clinical trials for obesity/weight loss and seem to work as well as (if not even better than) dual GLP-1R/GIPR agonists, such as tirzepatide (Zepbound ) (see below) [52]

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If periods become heavier , discuss with your GP whether iron supplementation is appropriate, particularly if you develop symptoms of anaemia such as fatigue, breathlessness, or pallor