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butyricum isolates suppressed fat formation and inflammation in high-fat diet models, with two strains substantially reducing weight gain

At 48 weeks, 64 to 100% of participants in the retatrutide groups had body-weight reductions of 5% or more, as compared with 27% of the participants in the placebo group

Most of the cases resulted from unintentional dosing or therapeutic errors rather than deliberate misuse

Although the short-term results are promising, post-treatment weight rebound and subsequent pregnancy outcomes are key factors that require validation through extended longitudinal studies

The next major deal may not simply be about buying another GLP-1 drug

That status changed in December 2025 with the FDA approval of an oral version of Wegovy (also manufactured by Novo Nordisk)