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Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe, unrelenting abdominal pain Signs of severe dehydration with confusion or altered consciousness Persistent vomiting with inability to retain any fluids for more than 24 hours Chest pain or difficulty breathing alongside gastrointestinal symptoms For patients with diabetes taking GLP-1 medications, persistent vomiting poses additional risks

Clinical trials are being run on combination therapies that can help preserve muscle massa big issue for GLP-1 usersand maybe even cut back on GI symptoms

Other studies mostly concentrate on the quantity of carbs

Diabetes 1997;46:615-21.ArticlePubMed 27

GLP-1 specific supplement packs Companies like Nature Made have released GLP-1 companion supplement packs specifically formulated for users of these medications

Abbreviations ADA: American Diabetes Association AE: Adverse event ASCVD: Atherosclerotic cardiovascular disease CI: Confidence interval CKD: Chronic kidney disease CVOT: Cardiovascular outcomes trial EASD: European Association for the Study of Diabetes eGFR: Estimated glomerular filtration rate GLP-1RA: Glucagon-like peptide-1 receptor agonist HbA1c: Hemoglobin A1c HF: Heart failure HHF: Hospitalization for heart failure HR: Hazard ratio MACE: Major adverse cardiovascular events OR: Odds ratio RCT: Randomized controlled trial RR: Relative risk SBP: Systolic blood pressure SGLT2i: Sodium-glucose cotransporter-2 inhibitor T2DM: Type 2 diabetes mellitus References Daz-Trastoy O, Villar-Taibo R, Sifontes-Dubn M, Mozo-Pealver H, Bernabeu-Morn I, Cabezas-Agrcola JM, et al