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Novo Nordisk's investment in prescriber education and patient support programs, combined with copay assistance initiatives that reduce out-of-pocket costs for commercially insured patients, has sustained Ozempic's prescription volume even as the market has expanded

9,10 This could be attributed to natriuresis and the improved function of the vascular endothelium facilitated by the release of nitric oxide

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Moreover, individuals with diabetes require continuous monitoring to prevent acute complications such as hypoglycemia and diabetic ketoacidosis

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Conversely, for DDES, some comparative evidence suggests that SGLT2 inhibitors may offer a greater risk reduction than GLP-1RAs [127]