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Retatrutide is a novel synthetic peptide designed as a triple agonist, targeting GLP-1, GIP, and glucagon receptors

Compared with other second- or third-line glucose-lowering medications, the GLP-1RAs demonstrated a lower rate of adverse CVEs, including heart failure (HR 0.88

Key milestones highlighted in this timeline: 1999 Orlistat (Xenical) The first long-term FDA-approved anti-obesity medication of the modern era

GLP-1s are not just another diabetes medication

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