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The therapeutic efficacy of poly-agonists is likely to change the treatment paradigm for obesity

In contrast, the pharmacological nanomolar concentrations of GLP-1RAs predominantly activate the cAMP/PKA pathway, potentially explaining their broader therapeutic effects [122]

The variability in available studies, potential confounding factors, and the severe heterogeneity of conclusions all emphasize the need for more high-quality evidence-based primary research to optimize perioperative management of patients taking GLP-1 RAs

Physical therapy evaluation can identify biomechanical issues and provide targeted interventions

are not subject to premarket review

Ozempic, which uses the active ingredient semaglutide, was approved in the US for diabetes in 2017 and subsequently in the UK, and its counterpart for weight loss, Wegovy, was approved in the US in 2021