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( 10.1056/NEJMoa1607141) [DOI] [PubMed] [Google Scholar] Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JFE, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, et al

A third incretin-based approach is tirzepatide, a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR), which achieves greater HbA1c reduction and weight loss compared with GLP-1RAs alone

Tirzepatide is delivered via a single-dose autoinjector pen where the needle is entirely hidden

We need to be evidence-based, he says

While head-to-head comparison data are preferable where available, NMA is a robust statistical approach that facilitates indirect comparison of multiple treatment options when direct comparative data are not available

Wait exactly 15 minutes after adding bacteriostatic water, with the vial stored at 28C during that period