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Will semaglutide make my Hashimoto's worse or trigger a thyroid flare

Follistatin is more immediately useful as a research target and a potential biomarker of PCOS severity than as a near-term treatment option

GLP-1 receptors are expressed throughout the central nervous system, including in the hypothalamus, which governs hunger and energy balance, and in the mesolimbic dopamine pathway the brain's reward circuit

While the few clinical trials completed so far have shown mixed results, the overall signals are encouraging

This finding aligns with previous studies, suggesting that short-acting agents may more readily cross the blood-brain barrier, thereby activating central GLP-1 receptors and exacerbating symptoms such as nausea and anorexia (Levin et al., 2017)

Hollander P, Bays HE, Rosenstock J, et al