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The phase 3 TRIUMPH-4 trial extended to 68 weeks and showed continued weight loss throughout, suggesting that longer maintenance periods produce better outcomes

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FDA Commissioner Marty Makary stated: "When FDA-approved drugs are available, outsourcing facilities cannot lawfully compound using bulk drug substances unless there is a clear clinical need." What this means for 503B facilities: If finalized, this proposal would permanently close the large-scale outsourcing facility compounding pathway for these three medications - regardless of future shortage conditions

Appetite Regulation The medication interacts with appetite centers in the brain, helping patients feel satisfied sooner during meals and reducing the urge to overeat

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